The authors have declared no competing interest. Our open-source, customizable agent-based model provides a sophisticated mechanism to quantitatively evaluate nuanced intervention strategies and inform the design of rational, locally relevant leptospirosis control programs. Assessment of alternate leptospirosis control strategies using model iterations revealed that dog vaccination and rodent control interventions had the most impact on lowering human outbreak probability. A key finding from model explorations is that rodents are the main contributors of rodent-adapted as well as dog-adapted strains in the environment, while dogs play an important role in distributing the rodent-adapted strain. Virtual explorations using MHMSLeptoDy were undertaken to evaluate alternate interventions and to assess the zoonotic transmission risk of leptospirosis. We developed the agent-based model MHMSLeptoDy to investigate Leptospira dynamics in a realistic, in silico high-density community of rodents, dogs, and human hosts, and two host-adapted Leptospira strains. Effective prevention of leptospirosis outbreaks will therefore require a thorough understanding of Leptospira transmission dynamics in impoverished, high-density settings. Moreover, continuing expansion of urban slums worldwide will likely contribute to the increase in outbreaks of leptospirosis. In marginalized communities, this approach is ineffective due to infrastructure deficiencies and the difficulties in implementing sanitation and hygiene practices. Due to the unavailability of safe and effective vaccines, preventive strategies mainly focus on minimizing human exposure to contaminated environment. Humans contract leptospirosis via exposure to water or soil contaminated with the urine of infected animals. A variety of animal species, including peridomestic rodents and dogs, can be infected with different strains of leptospirosis. Final prices are as marked.Leptospirosis, a neglected bacterial zoonosis, is a global public health issue disproportionately affecting impoverished communities such as urban slums in the developing world. The Sagebrook Home Bronze Elephant Bookends’s ornate animal motif offers an exotic touch to enhance your decor.Crafted from polyresin with a burnished metallic finish, this set brings antique-inspired elegance to your shelves, with hard-wearing construction to keep your. Promotion cannot be combined with any other offer and is not valid on Best Sellers, past purchases or towards purchases of gift cards. 20% Off Pillows, Floral, rugs, and Decor. Valid for purchases made from July 15th, 2022 - August 2nd, 2022 by 11:59 PM PST. Up to 25% Off Custom Sofas, Sectionals, Chairs, Benches and Ottomans. Valid for purchases made from July 7th, 2022 - July 26th, 2022 by 11:59 PM PST. Promotion cannot be combined with any other offer and is not valid on other departments, plush toys, sale items, past purchases or towards purchases of gift cards. Valid for purchases made from June 7th, 2022 - July 19th, 2022 by 11:59 PM PST. Promotion cannot be combined with any other offer and is not valid on books, Z Babie, plush toys, past purchases or towards purchases of gift cards. Up to 70% Off regular price items before taxes. Valid for purchases made from July 4th, 2022 - July 19th, 2022 by 11:59PM PST.
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